The changing faces of cholangitis [version 1; referees: 2 approved]

A variety of diseases are included under the umbrella term ‘cholangitis’, including hepatobiliary diseases with an autoimmune pathogenesis (such as primary sclerosing cholangitis, primary biliary cholangitis, and IgG4-associated sclerosing cholangitis) and disease processes associated with intraductal stones and infectious etiologies (such as ascending bacterial cholangitis, recurrent pyogenic cholangitis, and liver fluke-associated cholangitis). Recent advances in the pathophysiologic bases of these disorders, particularly with respect to the autoimmune variety, are allowing improved diagnosis and prognostication as well as providing the opportunity to refine and re-imagine treatment modalities. The aim of this review is to highlight selected advances in cholangitis research that point to novel insights into the pathophysiology, diagnosis, and treatment of this diverse array of disorders. Rahul Kuver ( ) Corresponding author: [email protected] Lee SP, Roberts JR and Kuver R. How to cite this article: The changing faces of cholangitis [version 1; referees: 2 approved] 2016, (F1000 Faculty Rev):1409 (doi: ) F1000Research 5 10.12688/f1000research.8745.1 © 2016 Lee SP . This is an open access article distributed under the terms of the , which Copyright: et al Creative Commons Attribution Licence permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The author(s) declared that no grants were involved in supporting this work. Grant information: Competing interests: The authors have no personal or financial competing interests to declare. 17 Jun 2016, (F1000 Faculty Rev):1409 (doi: ) First published: 5 10.12688/f1000research.8745.1 Referee Status: